Clinical Studies

ALSUntangled No. 26: lunasin.

Off-line two dimensional isoelectrofocusing-liquid chromatography/mass spectrometry (time of flight) for the determination of the bioactive peptide lunasin.

Activation of dendritic cell function by soypeptide lunasin as a novel vaccine adjuvant.

Efficient production of native lunasin with correct N-terminal processing by using the pH-induced self-cleavable Ssp DnaB mini-intein system in Escherichia coli.

Lunasin in wheat: a chemical and molecular study on its presence or absence.

Lunasin: attenuating effects on tumour growth in systemic malignancies.

Understanding Lunasin’s biology and potential as a cancer therapeutic by utilizing Drosophila genetics.

Bioactive peptides and hydrolysates from pulses and their potential use as functional ingredients.

Antioxidant activity and protective effects of peptide lunasin against oxidative stress in intestinal Caco-2 cells.

Soypeptide lunasin in cytokine immunotherapy for lymphoma.

Lunasin as a promising health-beneficial peptide.

Food Derived Bioactive Peptides on Inflammation and Oxidative Stress.

Activation of Natural Killer Cells by Soypeptide Lunasin and Cytokine Implication in Cancer Immunotherapy for Lymphoma.

Eukaryotic expression vectors containing genes encoding plant proteins for killing of cancer cells.

Lunasin-induced behavioural effects in mice: focus on the dopaminergic system.

Endocytic mechanism of internalization of dietary peptide lunasin into macrophages in inflammatory condition associated with cardiovascular disease.

Potential of Lunasin Orally-Administered in Comparison to Intraperitoneal Injection to Inhibit Colon Cancer Metastasis in Vivo.

Structural property of soybean lunasin and development of a method to quantify lunasin in plasma using an optimized immunoassay protocol.

Lunasin in cereal seeds: What is the origin?

Chemopreventive properties of Peptide Lunasin: a review.

The soybean peptide lunasin promotes apoptosis of mammary epithelial cells via induction of tumor suppressor PTEN: similarities and distinct actions from soy isoflavone genistein.

Isolation of low-molecular albumins of 2S fraction from soybean (Glycine max (L.) Merrill).

RGD-peptide lunasin inhibits Akt-mediated NF-κB activation in human macrophages through interaction with the αVβ3 integrin.

Bowman-Birk and Kunitz protease inhibitors among antinutrients and bioactives modified by germination and hydrolysis in Brazilian soybean cultivar BRS 133.

Analysis of lunasin in commercial and pilot plant produced soybean products and an improved method of lunasin purification.

Recombinant production of the therapeutic peptide lunasin.

Synthesis of the cancer preventive peptide lunasin by lactic acid bacteria during sourdough fermentation.

Scalable purification and characterization of the anticancer lunasin peptide from soybean.

Lunasin potentiates the effect of oxaliplatin preventing outgrowth of colon cancer metastasis, binds to α5β1 integrin and suppresses FAK/ERK/NF-κB signaling.

Differential gene expression of RAW 264.7 macrophages in response to the RGD peptide lunasin with and without lipopolysaccharide stimulation.

Lunasin and Bowman-Birk protease inhibitor concentrations of protein extracts from enzyme-assisted aqueous extraction of soybeans.

Relationship between lunasin’s sequence and its inhibitory activity of histones H3 and H4 acetylation.

Lunasin-aspirin combination against NIH/3T3 cells transformation induced by chemical carcinogens.

Differential expression of thrombospondin (THBS1) in tumorigenic and nontumorigenic prostate epithelial cells in response to a chromatin-binding soy peptide.

Lunasin induces apoptosis and modifies the expression of genes associated with extracellular matrix and cell adhesion in human metastatic colon cancer cells.

Soybean peptide lunasin suppresses in vitro and in vivo 7,12-dimethylbenz[a]anthracene-induced tumorigenesis.

Lunasin promotes apoptosis in human colon cancer cells by mitochondrial pathway activation and induction of nuclear clusterin expression.

The role of nutraceutical proteins and peptides in apoptosis, angiogenesis, and metastasis of cancer cells.

Recombinant expression of bioactive peptide lunasin in Escherichia coli.

Amaranth lunasin-like peptide internalizes into the cell nucleus and inhibits chemical carcinogen-induced transformation of NIH-3T3 cells.

Lunasin, a novel seed peptide, sensitizes human breast cancer MDA-MB-231 cells to aspirin-arrested cell cycle and induced apoptosis.

Lunasin peptide purified from Solanum nigrum L. protects DNA from oxidative damage by suppressing the generation of hydroxyl radical via blocking fenton reaction.

Lunasin, with an arginine-glycine-aspartic acid motif, causes apoptosis to L1210 leukemia cells by activation of caspase-3.

Complementary roles in cancer prevention: protease inhibitor makes the cancer preventive peptide lunasin bioavailable.

Lunasin is prevalent in barley and is bioavailable and bioactive in in vivo and in vitro studies.

Antioxidant and anti-inflammatory properties of cancer preventive peptide lunasin in RAW 264.7 macrophages.

Lunasin and lunasin-like peptides inhibit inflammation through suppression of NF-kappaB pathway in the macrophage.

Lunasin and Bowman-Birk protease inhibitor (BBI) in US commercial soy foods.

Isolation, purification and characterisation of lunasin from defatted soybean flour and in vitro evaluation of its anti-inflammatory activity.

Presence of lunasin in plasma of men after soy protein consumption.

Lunasin, a novel seed peptide for cancer prevention.

The cancer preventive seed peptide lunasin from rye is bioavailable and bioactive.

Bowman-Birk inhibitor and genistein among soy compounds that synergistically inhibit nitric oxide and prostaglandin E2 pathways in lipopolysaccharide-induced macrophages.

Analysis of soybean protein-derived peptides and the effect of cultivar, environmental conditions, and processing on lunasin concentration in soybean and soy products.

Lunasin: a novel cancer preventive seed peptide that modifies chromatin.

beta-Conglycinins among sources of bioactives in hydrolysates of different soybean varieties that inhibit leukemia cells in vitro.

Lunasin: a novel cancer preventive seed Peptide.

Bioactive peptides in amaranth (Amaranthus hypochondriacus) seed.

Cancer-preventive peptide lunasin from Solanum nigrum L. inhibits acetylation of core histones H3 and H4 and phosphorylation of retinoblastoma protein (Rb).

In vitro digestibility of the cancer-preventive soy peptides lunasin and BBI.

The cancer preventive peptide lunasin from wheat inhibits core histone acetylation.

Inhibition of core histone acetylation by the cancer preventive peptide lunasin.

Contents and bioactivities of lunasin, bowman-birk inhibitor, and isoflavones in soybean seed.

Lunasin: a cancer-preventive soy peptide.

Lunasin concentration in different soybean genotypes, commercial soy protein, and isoflavone products.

Dynamics of keratinocytes in vivo using HO labeling: a sensitive marker of epidermal proliferation state.

Characterization of lunasin isolated from soybean.

The anticarcinogenic potential of soybean lectin and lunasin.

Lunasin suppresses E1A-mediated transformation of mammalian cells but does not inhibit growth of immortalized and established cancer cell lines.

Barley lunasin suppresses ras-induced colony formation and inhibits core histone acetylation in mammalian cells.

Identification and bioavailability of a chromatin-binding peptide (Lunasin) from Korean Soybean.

Chemopreventive property of a soybean peptide (lunasin) that binds to deacetylated histones and inhibits acetylation.

A soybean cDNA encoding a chromatin-binding peptide inhibits mitosis of mammalian cells.

Amino acid sequence of a soybean (Glycine max) seed polypeptide having a poly(L-aspartic acid) structure.